Boron-containing and boron-omited derivatives based on the structural motif of capsaicin have been synthesized.The vanillyl amide moiety of the parent ALL PURPOSE BAKING FLOUR capsaicin molecule was retained and the boron atom was incorporated into the aliphatic region.All new compounds have been fully characterized using various analytical techniques including multinuclear NMR spectroscopy and elemental analysis.
Thereafter, their antiproliferative NEFF D95BMP5N0B N70 Built In 90cm 5 Speeds A Chimney Cooker Hood Stainless activity was evaluated on 3 cancer cell lines (HT-29, M21 and MCF7) leading to the selection of compounds 4c and 7c for assessment of their antitumoral activities on HT-29 tumors grafted onto the chorioallantoic membrane of developing chick embryos.The boro-capsaicinoid 4c exhibits good antitumoral activity with a 55% decrease in tumor mass.